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Transcellular transport often involves energy expenditure whereas paracellular transport is unmediated and passive down a concentration gradient, [4] or by osmosis (for water) and solvent drag for solutes. [5] Paracellular transport also has the benefit that absorption rate is matched to load because it has no transporters that can be saturated.
In contrast, paracellular transport is the transfer of substances across an epithelium by passing through an intercellular space between the cells. It differs from transcellular transport, where the substances travel through the cell passing through both the apical membrane and basolateral membrane; Renal physiology. Transcellular transport is ...
It generally occurs in the paracellular, rather than transcellular, pathway between the tubular cells. It is seen e.g. in the passive transport in renal sodium reabsorption, renal chloride reabsorption as well as renal urea handling.
Molecules are transported across an epithelial or endothelial barrier by one of two routes: 1) a transcellular route through the intracellular compartment of the cell, or 2) a paracellular route through the extracellular space between adjacent cells. [18] The transcellular route is also called transcytosis.
Two routes of Ca 2+ absorption are recognized: paracellular transport and transcellular transport (see Figure 4). [55] A high-Ca 2+-diet favors paracellular transport of the ion across the length of the intestine allowing them to pass between the intercellular tight junctions that connect epithelial cells.
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The transcellular fluid is the portion of total body fluid that is formed by the secretory activity of epithelial cells and is contained within specialized epithelial-lined compartments. Fluid does not normally collect in larger amounts in these spaces, [6] [7] and any significant fluid collection in these spaces is physiologically ...
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