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A lower dose should be used in people with liver disease. [2] While it does not appear to be harmful during pregnancy, it has not been studied for this use. [3] It is unclear if it is safe for use during breastfeeding. [2] It is in the antihelmintic family of medications. [4] It works by paralyzing worms. [4] Pyrantel was initially described in ...
3.5 times more likely to cause easily reversible but unpleasant severe stiffening of muscles, around 6% with chlorpromazine: RR 3.5 CI 1.5 to 8.0 Parkinsonism: 2 times more likely to cause parkinsonism (symptoms such as tremor, hesitancy of movement, decreased facial expression), around 17% with chlorpromazine: RR 2.1 CI 1.6 to 2.8
Pinworms are particularly common in children with approximately 30% of children being infected and most commonly seen in children between 7 and 11 years old. [34] The prevalence rates in children having been reported as high as 61% in India, 50% in England, 39% in Thailand, 37% in Sweden, and 29% in Denmark. [ 18 ]
[6] [7] It is taken by mouth. [5] Mebendazole is usually well tolerated. [5] Common side effects include headache, vomiting, and ringing in the ears. [5] If used at large doses it may cause bone marrow suppression. [5] It is unclear if it is safe in pregnancy. [5] [2] Mebendazole is a broad-spectrum antihelminthic agent of the benzimidazole ...
Metabolites have a half-life of 4 to 5 hours. In patients with significantly impaired liver function (Child-Pugh score B and C), the serum half-life is increased to 3 to 8 hours. Praziquantel and its metabolites are mainly excreted renally; within 24 h after a single oral dose, 70 to 80% is found in urine, but less than 0.1% as the unchanged drug.
Stochastic health effects are those that occur by chance, and whose probability is proportional to the dose, but whose severity is independent of the dose. [3] The LNT model assumes there is no lower threshold at which stochastic effects start, and assumes a linear relationship between dose and the stochastic health risk.
Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
The researchers found that this rate increased by about 300% (from 1.5 cases to 6.0 cases per 1,000 hospital births) during 1999 to 2013. Along with these results, there have been considerable differences in state NAS incidence, with lows and highs ranging from 0.7 per 1,000 births in Hawaii, to 33.4 per 1,000 births in West Virginia.