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Acute erythroid leukemia is rare, accounting for only 3–5% of all acute myeloid leukemia cases. [2] One study estimated an occurrence rate of 0.077 cases per 100,000 people each year. [ 12 ] 64–70% of people with this condition are male, and most are elderly, with a median age of 65.
The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. [1] Diagnosis is generally based on bone marrow aspiration and specific blood tests. [3] AML has several subtypes for which treatments and outcomes may vary. [1]
The criteria for an acute myeloid leukemia case to fall under the M2 subtype is the following: 20%+ nonerythroid cells in peripheral blood or bone marrow are myeloblasts; monocytic precursors are < 20% in bone marrow and granulocytes are 10%+ of cells (Mihova, 2013).
The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, white blood cells, and platelets. [1] Diagnosis is typically based on blood tests and bone marrow examination. [3] Acute lymphoblastic leukemia is typically treated initially with chemotherapy aimed at bringing about remission. [2]
Damage to the bone marrow, by way of displacing the normal bone marrow cells with higher numbers of immature white blood cells, results in a lack of blood platelets, which are important in the blood clotting process. This means people with leukemia may easily become bruised, bleed excessively, or develop pinprick bleeds . [36]
Acute myelomonocytic leukemia (AMML) is a form of acute myeloid leukemia that involves a proliferation of CFU-GM myeloblasts and monoblasts. AMML occurs with a rapid increase amount in white blood cell count and is defined by more than 20% of myeloblast in the bone marrow. It is classified under "M4" in the French-American-British ...
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