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Tobramycin/dexamethasone, sold under the brand name Tobradex, is a fixed-dose combination medication in the form of eye drops and eye ointment, marketed by Alcon. [1] [2] [3] The active ingredients are tobramycin (an antibiotic) and dexamethasone (a corticosteroid). [2] It is prescribed for the treatment of pink eye in combination with ...
Tobramycin is on the World Health Organization's List of Essential Medicines. [11] In 2022, tobramycin was the 281st most commonly prescribed medication in the United States, with more than 600,000 prescriptions. [12] Tobrex eye drops are a 0.3% tobramycin sterile ophthalmic solution produced by Alcon Pharmaceuticals.
Fexofenadine, an antihistamine drug used in treatment of allergies, has shown promise in a combination therapy in some studies. [ 197 ] [ 198 ] Opportunely, low gastrointestinal absorption (or high absorbed drug gastrointestinal secretion) of fexofenadine results in higher concentration at the site of inflammation.
When applied to the surface of the eye, side effects may include a brief period of blurry vision and discoloration of contact lenses of the soft type. [7] [3] When used by mouth or injection, side effects may include headache, nausea, and a change to the color of the skin for a brief period of time. [3] Allergic reactions may rarely occur. [3]
Common side effects include red eyes, dry eyes, change in color of the eyes, blurry vision, and cataracts. [ 5 ] [ 6 ] [ 4 ] Use during pregnancy or breastfeeding is generally not recommended. [ 1 ] [ 6 ] [ 4 ] It is a prostaglandin analog and works by increasing the outflow of aqueous fluid from the eyes.
Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1]