Search results
Results From The WOW.Com Content Network
Just as a nucleoside can be considered as a nucleotide without a phosphate group, so too a deoxyribonucleoside is a deoxyribonucleotide without a phosphate. [2] An example is deoxycytidine . References
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group.A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotide is composed of a nucleobase, a five-carbon sugar, and one or more phosphate groups.
Ribonucleoside diphosphate (NDP) is reduced by thioredoxin to a deoxyribonucleoside diphosphate (dNTP). The general reaction is: Ribonucleoside diphosphate + NADPH + H + → Deoxyribonucleoside diphosphate + NADP + + H 2 O [11] To illustrate this equation, dATP and dGTP are synthesized from ADP and GDP, respectively.
A nucleoside triphosphate is a nucleoside containing a nitrogenous base bound to a 5-carbon sugar (either ribose or deoxyribose), with three phosphate groups bound to the sugar. [1]
This nucleotide contains the five-carbon sugar deoxyribose (at center), a nucleobase called adenine (upper right), and one phosphate group (left). The deoxyribose sugar joined only to the nitrogenous base forms a Deoxyribonucleoside called deoxyadenosine, whereas the whole structure along with the phosphate group is a nucleotide, a constituent of DNA with the name deoxyadenosine monophosphate.
Ribonucleotide reductase (RNR), also known as ribonucleoside diphosphate reductase, is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides. [ 1 ] [ 2 ] It catalyzes this formation by removing the 2'-hydroxyl group of the ribose ring of nucleoside diphosphates (or triphosphates depending on the class of RNR).
Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine, but with one hydroxyl group removed from the C2' position. Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase, converting it to deoxycytidine monophosphate (dCMP), a DNA precursor.
Unlike the other deoxyribonucleoside triphosphates, thymidine triphosphate does not always contain the "deoxy" prefix in its name. [2] This is because dTTP does not have a corresponding ribonucleoside triphosphate, as the uridine triphosphate , which lacks thymidine's 5-methylation , is used instead.