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  2. Liquid chromatography–mass spectrometry - Wikipedia

    en.wikipedia.org/wiki/Liquid_chromatography...

    Liquid chromatography–mass spectrometry (LCMS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography – MS systems are popular in chemical analysis because the individual capabilities ...

  3. High-performance liquid chromatography - Wikipedia

    en.wikipedia.org/wiki/High-performance_liquid...

    Therefore, HPLC in this context is often performed in conjunction with mass spectrometry. [65] Using liquid chromatography-mass spectrometry (LC-MS) instead of gas chromatography-mass spectrometry (GC-MS) circumvents the necessity for derivitizing with acetylating or alkylation agents, which can be a burdensome extra step. [66]

  4. Direct electron ionization liquid chromatography–mass ...

    en.wikipedia.org/wiki/Direct_electron_ionization...

    However, the possibility to record an EI spectrum from an HPLC application remained a challenge for a long time. The first Direct-EI prototype was first presented in 2002 [5] and proposed an innovative approach that improved interfacing performance compared to that of particle beam and opened new opportunities for LC-MS applications.

  5. Monolithic HPLC column - Wikipedia

    en.wikipedia.org/wiki/Monolithic_HPLC_column

    Analysis of buprenorphine, a heroin substitute, demonstrated the potential utility of multidimensional LC as a low-level detection method. HPLC methods can measure this compound at 40 ng/mL, compared to GC-MS at 0.5 ng/mL, but LC-MS-MS can detect buprenorphine at levels as low as 0.02 ng/mL. The sensitivity of multidimensional LC is therefore ...

  6. Sample preparation in mass spectrometry - Wikipedia

    en.wikipedia.org/wiki/Sample_preparation_in_mass...

    HPLC ESI TOF. Liquid chromatography (LC) is a method that in some ways is more powerful than GC, but can be coupled to mass spectrometry just as easily. In LC, the concerns involving sample preparation can be minimal. In LC, both the stationary and mobile phase can affect the separation, whereas in GC only the stationary phase should be ...

  7. Mass chromatogram - Wikipedia

    en.wikipedia.org/wiki/Mass_chromatogram

    An example total ion current chromatogram from an LC-MS analysis. The total ion current chromatogram (TICC) represents the summed intensity across the entire range of masses being detected at every point in the analysis. [2] [3] The range is typically several hundred mass-to-charge units or more. In complex samples, the TICC often provides ...

  8. Electrospray ionization - Wikipedia

    en.wikipedia.org/wiki/Electrospray_ionization

    Electrospray ionization is the ion source of choice to couple liquid chromatography with mass spectrometry (LC-MS). The analysis can be performed online, by feeding the liquid eluting from the LC column directly to an electrospray, or offline, by collecting fractions to be later analyzed in a classical nanoelectrospray-mass spectrometry setup.

  9. Reversed-phase chromatography - Wikipedia

    en.wikipedia.org/wiki/Reversed-phase_chromatography

    Reversed-phase liquid chromatography (RP-LC) is a mode of liquid chromatography in which non-polar stationary phase and polar mobile phases are used for the separation of organic compounds. [ 1 ] [ 2 ] [ 3 ] The vast majority of separations and analyses using high-performance liquid chromatography (HPLC) in recent years are done using the ...