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  2. Angiotensin II receptor blocker - Wikipedia

    en.wikipedia.org/wiki/Angiotensin_II_receptor...

    Losartan, the first ARB. Angiotensin II receptor blockers (ARBs), formally angiotensin II receptor type 1 (AT 1) antagonists, [1] also known as angiotensin receptor blockers, [2] [3] angiotensin II receptor antagonists, or AT 1 receptor antagonists, are a group of pharmaceuticals that bind to and inhibit the angiotensin II receptor type 1 (AT 1) and thereby block the arteriolar contraction and ...

  3. Bioavailability - Wikipedia

    en.wikipedia.org/wiki/Bioavailability

    [2] [3] However, when a medication is administered via routes other than intravenous, its bioavailability is lower due to intestinal epithelium absorption and first-pass metabolism. Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular ...

  4. Pharmacokinetics - Wikipedia

    en.wikipedia.org/wiki/Pharmacokinetics

    Steady state is reached after about 5 × 12 = 60 hours. Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics ), sometimes abbreviated as PK , is a branch of pharmacology dedicated to describing how the body affects a specific substance after administration. [ 1 ]

  5. ACE inhibitor - Wikipedia

    en.wikipedia.org/wiki/ACE_inhibitor

    Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a class of medication used primarily for the treatment of high blood pressure and heart failure. [1] [2] This class of medicine works by causing relaxation of blood vessels as well as a decrease in blood volume, which leads to lower blood pressure and decreased oxygen demand from the heart.

  6. Kingsbrook Jewish Medical Center - Wikipedia

    en.wikipedia.org/wiki/Kingsbrook_Jewish_Medical...

    Kingsbrook Jewish Medical Center was a 303-bed full-service community teaching hospital with an estimated 2,100 full-time employees, located in the neighborhood of East Flatbush in Brooklyn, New York. The hospital was made up of a complex of eight conjoined buildings which are dispersed over a 366,000 square foot city block.

  7. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    [187] [188] Fluvoxamine is an agonist of the σ 1 receptor, while sertraline is an antagonist of the σ 1 receptor, and paroxetine does not significantly interact with the σ 1 receptor. [187] [188] None of the SSRIs have significant affinity for the σ 2 receptor. [187] [188] Fluvoxamine has by far the strongest activity of the SSRIs at the σ ...

  8. Fetal alcohol spectrum disorder - Wikipedia

    en.wikipedia.org/wiki/Fetal_alcohol_spectrum...

    As of 2016, the US Centers for Disease Control estimated 3 million women in the United States are at risk of having a baby with FASD. [116] FASD is estimated to affect between 1-2% and 5% of people in the United States and Western Europe. [117] FAS is believed to occur in between 0.2 and 9 per 1,000 live births in the United States. [117]

  9. Blood–brain barrier - Wikipedia

    en.wikipedia.org/wiki/Blood–brain_barrier

    The drugs that remain in the passage after mucociliary clearance, enter the brain via three pathways: (1) Olfactory nerve-olfactory bulb-brain; (2) Trigeminal nerve-brain; and (3) Lungs/ Gastrointestinal tract-blood–brain [35] The first and second methods involve the nerves, so they use the neuronal pathway and the third is via systemic ...

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