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  2. Pathology of multiple sclerosis - Wikipedia

    en.wikipedia.org/.../Pathology_of_multiple_sclerosis

    It also seems that myelin basic protein (MBP) from multiple sclerosis (MS) patients contains lower levels of phosphorylation at Thr97 than normal individuals. [152] NAWM is the place where lesions appear and the process seems to be made by microglia, in absence of leukocyte infiltration, astrogliosis or demyelination.

  3. Pathophysiology of multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Pathophysiology_of...

    The damaged white matter is known as "Normal-appearing white matter" (NAWM) and is where lesions appear. [10] These lesions form in NAWM before blood–brain barrier breakdown. [64] BBB can be broken centripetally (the most normal) or centrifugally. [65] Several possible biochemical disrupters were proposed.

  4. Lesional demyelinations of the central nervous system

    en.wikipedia.org/wiki/Lesional_demyelinations_of...

    Demyelinating lesions whose size is larger than 2 cm. They normally appear together with normal MS lesions, situation described as tumefactive multiple sclerosis. When they appear alone, they are usually named "Solitary sclerosis", [38] being more difficult to diagnose.

  5. Multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Multiple_sclerosis

    The McDonald criteria states that patients with multiple sclerosis should have lesions which are disseminated in time (DIT) and disseminated in space (DIS), i.e. lesions which have appeared in different areas in the brain and at different times. [88] Below is an abbreviated outline of the 2017 McDonald Criteria for diagnosis of MS.

  6. Oligoclonal band - Wikipedia

    en.wikipedia.org/wiki/Oligoclonal_band

    New techniques like "capillary isoelectric focusing immunoassay" are able to detect IgG OCBs in more than 95% of multiple sclerosis patients. [ 7 ] Even more than 12 OCBs can appear in MS. [ 8 ] Each one of them represent antibody proteins (or protein fragments) secreted by plasma cells , although why exactly these bands are present, and which ...

  7. White matter - Wikipedia

    en.wikipedia.org/wiki/White_matter

    Multiple sclerosis (MS) is the most common of the inflammatory demyelinating diseases of the central nervous system which affect white matter. In MS lesions, the myelin sheath around the axons is deteriorated by inflammation. [10] Alcohol use disorders are associated with a decrease in white matter volume. [11]

  8. Disturbing video shows hundreds of maggots removed from ... - AOL

    www.aol.com/news/2014-11-18-disturbing-video...

    By RYAN GORMAN Horrifying video has emerged of doctors pulling maggots out of a man's ear. The unidentified Indian man went to a doctor's office to complain about hearing a non-stop buzzing sound.

  9. Biomarkers of multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Biomarkers_of_multiple...

    Currently the best predictor for clinical multiple sclerosis is the number of T2 lesions visualized by MRI during the CIS, but it has been proposed to complement it with MRI measures of BBB permeability [97] It is normal to evaluate diagnostic criteria against the "time to conversion to definite".

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