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Phenylhydrazine was the first hydrazine derivative characterized, reported by Hermann Emil Fischer in 1875. [7] [8] He prepared it by reduction of a phenyl diazonium salt using sulfite salts. Fischer used phenylhydrazine to characterize sugars via formation of hydrazones known as osazones with the sugar aldehyde. He also demonstrated in this ...
Statue of Mayo near the Mayo Clinic in Rochester, Minnesota. In 1851, Mayo married Louise Abigail Wright (December 23, 1825 – July 15, 1915), and two years later, they had their first child, Gertrude. Around this time, Mayo left for a winter to work as an assistant at the University of Missouri's medical department.
As of 2023, Mayo Clinic Hospital in Arizona has been ranked No.1 in Arizona and the Phoenix metro area as part of U.S. News & World Report’s “Best Hospitals” rankings. In addition, for a sixth consecutive year, Mayo Clinic in Arizona was recognized on the "Best Hospitals Honor Roll" which recognizes the top 20 hospitals in the nation.
Since 1977, the WHO has published a model list of essential medicines, with the 2019 list for adult patients containing over 400 medicines. [3] Since 2007, a separate list of medicines intended for child patients has been published. [4] A new list was published in 2021, for both adults and children. [5]
Most have been withdrawn due to toxicity, namely hepatotoxicity, but a few still remain in clinical use. Tranylcypromine , a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing hepatotoxicity .
Phenyltropanes (PTs) are a family of chemical compounds originally derived from structural modification of cocaine.The main feature differentiating phenyltropanes from cocaine is that they lack the ester functionality at the 3-position terminating in the benzene; and thusly the phenyl is attached direct to the tropane skeleton with no further spacer (therefore the name "phenyl"-tropane) that ...
It is used in the treatment of itchiness, anxiety, insomnia, and nausea (including that due to motion sickness). [8] It is used either by mouth or injection into a muscle. [8] Hydroxyzine works by blocking the effects of histamine. [9] It is a first-generation antihistamine in the piperazine family of chemicals.
Phenylephrine, sold under the brand names Neosynephrine and Sudafed PE among others, is a medication used as a decongestant for uncomplicated nasal congestion in the form of a nasal spray or oral tablet, [5] to dilate the pupil, to increase blood pressure given intravenously in cases of low blood pressure, and to relieve hemorrhoids as a suppository.