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Ciclopirox is a medication used for the treatment of moderate onychomycosis of fingernails and toenails, [3] and for the treatment of seborrheic dermatitis. [ 4 ] In 2022, it was the 247th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
Ciclopirox and ciclopirox olamine are synthetic antifungal agents. The exact mechanism of action of Ciclopirox olamine antifungals is not well understood. It appears that the medication works by causing depletion of important substrates such as amino acids and/or ions within fungal cells, resulting in the inhibition of transport of these ...
Topical steroids are used to relieve the symptoms of seborrheic dermatitis. It has a fungicidal action, and reduces dandruff. [4] The disadvantage is that it has a high relapse rate on discontinuation. Prolonged use can cause poor healing of wounds.
Specifically, ketoconazole or ciclopirox are effective. [10] Seborrhoeic dermatitis of the scalp is often treated with shampoo preparations of ketoconazole zinc pyrithione, and selenium, although the latter has been partly discontinued due to concerns of selenium in higher concentrations being carcinogenic. [11]
There is a ciclopirox-containing nail polish, but there is no evidence that it works. [2] The condition returns in up to half of cases following treatment. [2] Not using old shoes after treatment may decrease the risk of recurrence. [3] Onychomycosis occurs in about 10 percent of the adult population, [2] with older people more frequently ...
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
Ciclopirox (topical route) may also be used as an anti-dandruff agent. [25] [26] [27] However, it is mostly sold as cream and its main use is for treating athlete's foot, jock itch, and ringworm. [28] Other than zinc pyrithione, the most common anti-dandruff actives (outside the US) and part of many cosmetic shampoos, are piroctone olamine and ...
The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer (see figure), where each zinc is bonded to two sulfur and three oxygen centers. [3]