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Intention-to-treat analysis. In medicine an intention-to-treat (ITT) analysis of the results of a randomized controlled trial is based on the initial treatment assignment and not on the treatment eventually received. ITT analysis is intended to avoid various misleading artifacts that can arise in intervention research such as non-random ...
However, by restricting the analysis to a selected patient population, it does not show all effects of the new drug. Further, adherence to treatment may be affected by other factors that influence the outcome. Accordingly, per-protocol effects are at risk of bias, whereas the intent-to-treat estimate is not. [7]
By one of the three pre-decided statistical tests for analysis of the trial there was a statistically significant lower rate of infection in the vaccine group compared to the placebo group, with p=0.04 for the "modified intent to treat" analysis that excluded persons who were found to have HIV infection after enrollment but before the first ...
Zelen's design is an experimental design for randomized clinical trials proposed by Harvard School of Public Health statistician Marvin Zelen (1927-2014). In this design, patients are randomized to either the treatment or control group before giving informed consent. Because the group to which a given patient is assigned is known, consent can ...
Local average treatment effect. In econometrics and related empirical fields, the local average treatment effect (LATE), also known as the complier average causal effect (CACE), is the effect of a treatment for subjects who comply with the experimental treatment assigned to their sample group. It is not to be confused with the average treatment ...
According to the World Bank's Independent Evaluation Group (IEG), impact evaluation is the systematic identification of the effects positive or negative, intended or not on individual households, institutions, and the environment caused by a given development activity such as a program or project. [24]
Number needed to treat. Group exposed to a treatment (left) has reduced risk of an adverse outcome (grey) compared to the unexposed group (right). 4 individuals need to be treated to prevent 1 adverse outcome (NNT = 4). The number needed to treat (NNT) or number needed to treat for an additional beneficial outcome (NNTB) is an epidemiological ...
Contract law. Offer and acceptance are generally recognized as essential requirements for the formation of a contract (together with other requirements such as consideration and legal capacity). Analysis of their operation is a traditional approach in contract law. This classical approach to contract formation has been modified by developments ...