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In genetics, a transcription terminator is a section of nucleic acid sequence that marks the end of a gene or operon in genomic DNA during transcription.This sequence mediates transcriptional termination by providing signals in the newly synthesized transcript RNA that trigger processes which release the transcript RNA from the transcriptional complex.
Termination of transcription occurs in the ribosomal intergenic spacer region that contains several transcription termination sites upstream of a Pol I pausing site. Through a yet unknown mechanism, the 3’-end of the transcript is cleaved, generating a large primary rRNA molecule that is further processed into the mature 18S, 5.8S and 28S rRNAs.
Overview of transcription process. Termination of transcription occurs due to termination signal. In molecular biology, a termination signal is a sequence that signals the end of transcription or translation. [1] Termination signals are found at the end of the part of the chromosome being transcribed during transcription of mRNA.
RNA polymerase, assisted by one or more general transcription factors, then selects a transcription start site in the transcription bubble, binds to an initiating NTP and an extending NTP (or a short RNA primer and an extending NTP) complementary to the transcription start site sequence, and catalyzes bond formation to yield an initial RNA product.
Intrinsic, or rho-independent termination, is a process to signal the end of transcription and release the newly constructed RNA molecule. In bacteria such as E. coli , transcription is terminated either by a rho-dependent process or rho-independent process.
The following other wikis use this file: Usage on cs.wikipedia.org Transkripce (DNA) Usage on da.wikipedia.org Proteinbiosyntese; Usage on en.wikibooks.org Proteomics/Protein Primary Structure/Genetic Code; An Introduction to Molecular Biology/Transcription of RNA and its modification; Principles of Biochemistry/Cell Metabolism II: RNA ...