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Use of anticonvulsant medications should be carefully monitored during use in pregnancy. [94] For example, since the first trimester is the most susceptible period for fetal development, planning a routine antiepileptic drug dose that is safer for the first trimester could be beneficial to prevent pregnancy complications. [95]
A package of topiramate 25mg from Norway. Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. [19] In children, it is indicated for the treatment of Lennox-Gastaut syndrome, a disorder that causes seizures and developmental delay.
Primidone is an anticonvulsant of the barbiturate class; [7] however, its long-term effect in raising the seizure threshold is likely due to its active metabolite, phenobarbital. [10] The drug’s other active metabolite is phenylethylmalonamide (PEMA). Primidone was approved for medical use in the United States in 1954. [7]
About 20% of children on the ketogenic diet achieve freedom from seizures, and many are able to reduce the use of anticonvulsant drugs or eliminate them altogether. [18] Commonly, at around two years on the diet, or after six months of being seizure-free, the diet may be gradually discontinued over two or three months.
Although there are many medications to help prevent seizures, there are still more than 30% of the 70 million people that have drug resistant seizures throughout their life. There are 20% of children that have shown to be pharmacoresistance to trials of multiple antiepileptic drugs.
Studies for the use of ESL as an anticonvulsant for children are under way as of 2016. [16] Like oxcarbazepine, ESL has potential uses for the treatment of trigeminal neuralgia [citation needed] and bipolar disorder. A 2015 assessment showed no statistical difference to placebo for the latter disorder. [17]
Tiagabine (trade name Gabitril) is an anticonvulsant medication produced by Cephalon that is used in the treatment of epilepsy. The drug is also used off-label in the treatment of anxiety disorders and panic disorder .
Stiripentol, sold under the brand name Diacomit, is an anticonvulsant medication used for the treatment of Dravet syndrome - a serious genetic brain disorder. [5] [6]The most common side effects include loss of appetite, weight loss, insomnia (difficulty sleeping), drowsiness, ataxia (inability to co‑ordinate muscle movements), hypotonia (low muscle strength) and dystonia (muscle disorders).
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