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It is also called n-octanol-water partition ratio. [2] [3] [4] K ow serves as a measure of the relationship between lipophilicity (fat solubility) and hydrophilicity (water solubility) of a substance. The value is greater than one if a substance is more soluble in fat-like solvents such as n-octanol, and less than one if it is more soluble in ...
This ratio is therefore a comparison of the solubilities of the solute in these two liquids. The partition coefficient generally refers to the concentration ratio of un-ionized species of compound, whereas the distribution coefficient refers to the concentration ratio of all species of the compound (ionized plus un-ionized). [1]
HLB scale showing classification of surfactant function. The hydrophilic–lipophilic balance (HLB) of a surfactant is a measure of its degree of hydrophilicity or lipophilicity, determined by calculating percentages of molecular weights for the hydrophilic and lipophilic portions of the surfactant molecule, as described by Griffin in 1949 [1] [2] and 1954. [3]
[3] [4] If an anesthetic has a high coefficient, then a large amount of it will have to be taken up in the body's blood before being passed on to the fatty (lipid) tissues of the brain where it can exert its effect. The potency of an anesthetic is associated with its lipid solubility, which is measured by its oil/gas partition coefficient. [5]
Lipophilic efficiency [1] (LiPE), sometimes referred to as ligand-lipophilicity efficiency (LLE) is a parameter used in drug design and drug discovery to evaluate the quality of research compounds, linking potency and lipophilicity in an attempt to estimate druglikeness.
Example of saponification reaction of a triglyceride molecule (left) with potassium hydroxide (KOH) yielding glycerol (purple) and salts of fatty acids ().. Saponification value or saponification number (SV or SN) represents the number of milligrams of potassium hydroxide (KOH) or sodium hydroxide (NaOH) required to saponify one gram of fat under the conditions specified.
Cholesterol ratios above 5.0 are an indicator of heart disease, which could affect how much you pay for life insurance. Diabetes: Both Type 1 and 2 diabetes can affect your approval and risk ...
IV can be also predicted from near-infrared, FTIR and Raman spectroscopy data using the ratio between the intensities of ν(C=C) and ν(CH 2) bands. [ 14 ] [ 15 ] High resolution proton-NMR provides also fast and reasonably accurate estimation of this parameter.