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Amlodipine causes several drugs to increase in levels, including cyclosporine, simvastatin, and tacrolimus (the increase in the last one being more likely in people with CYP3A5*3 genetic polymorphisms). [39] When more than 20 mg of simvastatin, a lipid-lowering agent, are given with amlodipine, the risk of myopathy increases. [40]
This can progress to the heart stopping altogether. [2] CCBs of the dihydropyridine group, as well as flunarizine, predominantly cause reflex tachycardia as a reaction to the low blood pressure. [4] [5] [6] Other potential symptoms include: nausea and vomiting, a decreased level of consciousness, and breathing difficulties. [2]
[1] [2] Hyperkalemia can cause an abnormal heart rhythm which can result in cardiac arrest and death. [1] [3] Common causes of hyperkalemia include kidney failure, hypoaldosteronism, and rhabdomyolysis. [1] A number of medications can also cause high blood potassium including spironolactone, NSAIDs, and angiotensin converting enzyme inhibitors. [1]
Dihydropyridine calcium channel blockers can worsen proteinuria in patients with nephropathy. [9] This CCB class is easily identified by the suffix "-dipine". Amlodipine (Norvasc) Aranidipine (Sapresta) Azelnidipine (Calblock) Barnidipine (HypoCa) Benidipine (Coniel) Cilnidipine (Atelec, Cinalong, Siscard) Not available in US; Clevidipine ...
Potassium-sparing diuretics or antikaliuretics [1] refer to drugs that cause diuresis without causing potassium loss in the urine. [2] They are typically used as an adjunct in management of hypertension, cirrhosis, and congestive heart failure. [3] The steroidal aldosterone antagonists can also be used for treatment of primary hyperaldosteronism.
Amlodipine/benazepril, sold under the brand name Lotrel among others, is a fixed-dose combination medication used to treat high blood pressure. [1] It is a combination of amlodipine, as the besilate, a calcium channel blocker, and benazepril, an angiotensin converting enzyme inhibitor. [1] It may be used if a single agent is not sufficient. [1]
Low GABA levels can lead to heightened stress, manifesting as overwhelming feelings, disorganization, excessive worrying, and insomnia due to racing thoughts. This deficiency is associated with ...
For example, people that are taking Digitalis (i.e. digoxin) are at higher risk for changes in heart rhythm if their potassium levels get too high. [6] The 2017 clinical practice guidelines of the American College of Cardiology / American Heart Association Task Force on Clinical Practice Guidelines list amiloride as a "secondary" oral ...