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A latrotoxin is a high-molecular mass neurotoxin found in the venom of spiders of the genus Latrodectus (widow spiders) as well as at least one species of another genus in the same family, Steatoda nobilis. [1] Latrotoxins are the main active components of the venom and are responsible for the symptoms of latrodectism.
Latrodectism (/ l æ t r ə ˈ d ɛ k t ɪ z əm /) is the illness caused by the bite of Latrodectus spiders (the black widow spider and related species). Pain, muscle rigidity, vomiting, and sweating are the symptoms of latrodectism.
Spiders of the genus Latrodectus have α-latrotoxin in their venom. The most well known spider in this genus is the black widow spider. α-latrotoxin causes the release of neurotransmitters into the synaptic gap, including acetylcholine. [25] Bites are usually not fatal, but do cause a significant amount of pain in addition to muscle spasms.
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If possible, have on hand the pill bottle, medication package or other suspect container. [25] The treatment will depend on the substance to which the patient is exposed. Depending on the type of poisoning, some first aid measures may help. Treatments include activated charcoal, induction of vomiting and dilution or neutralizing of the poison. [26]
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The actual amount injected, even by a mature female, is variable. The venom injected by the female black widow is known as alpha-latrotoxin which binds to receptors at the neuromuscular motor end plate of both sympathetic and parasympathetic nerves, resulting in increased synaptic concentration of catecholamines. The symptoms are caused by ...