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The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk. Every drug has specific information listed in its product literature.
Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). [2] [3] [4]Salts of this anion, especially docusate sodium, are widely used in medicine as an emollient laxative and as stool softeners, by mouth or rectally. [1]
Summary chart: A summary chart that is color coded, with green used for category 1 and 2 methods and pink/red used for category 3 and 4 methods, exists to provide reference to select methods and their categories. Summary wheel: A summary wheel exists that details categories in a slightly different format than the summary chart. [4]
The FDA has assigned lacosamide to pregnancy category C. Animal studies have reported incidences of fetal mortality and growth deficit. Lacosamide has not been tested during human pregnancy, and should be administered with caution. In addition, it has not been determined whether the excretion of lacosamide occurs in breast milk. [7]
On 17 November 2004, the United States Food and Drug Administration put a black box warning on the label, indicating that there were potential adverse effects of loss of bone mineral density. [ 100 ] [ 101 ] While it causes temporary bone loss , most women fully regain their bone density after discontinuing use. [ 75 ]
There is no clear first-line tocolytic agent. [6] [7] Current evidence suggests that first line treatment with β 2 agonists, calcium channel blockers, or NSAIDs to prolong pregnancy for up to 48 hours is the best course of action to allow time for glucocorticoid administration.
The Robson classification, also known as the 10-groups classification or ten groups classification system (TGCS), is a system for classifying pregnant women who undergo childbirth. It was developed to allow more accurate comparison of caesarean section rates between different settings, whether they be individual hospitals or entire regions or ...
Use appears to be safe during pregnancy. [9] [3] It is classified as an osmotic laxative: [4] It works by increasing the amount of water in the stool. [5] Macrogol came into use as a bowel prep in 1980 and was approved for medical use in the United States in 1999. [10] [11] [12] It is available as a generic medication and over the counter.