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  2. Retinoblastoma - Wikipedia

    en.wikipedia.org/wiki/Retinoblastoma

    Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, [2] the light-detecting tissue of the eye. [3] It is the most common primary malignant intraocular cancer in children, and 80% of retinoblastoma cases are first detected in those under 3 years old.

  3. RBBP5 - Wikipedia

    en.wikipedia.org/wiki/RBBP5

    213464 Ensembl ENSG00000117222 ENSMUSG00000026439 UniProt Q15291 Q8BX09 RefSeq (mRNA) NM_001193272 NM_001193273 NM_005057 NM_172517 NM_001357486 NM_001357487 RefSeq (protein) NP_001180201 NP_001180202 NP_005048 NP_766105 NP_001344415 NP_001344416 Location (UCSC) Chr 1: 205.09 – 205.12 Mb Chr 1: 132.41 – 132.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinoblastoma-binding ...

  4. RBBP8 - Wikipedia

    en.wikipedia.org/wiki/RBBP8

    5932 225182 Ensembl ENSG00000101773 ENSMUSG00000041238 UniProt Q99708 Q80YR6 RefSeq (mRNA) NM_002894 NM_203291 NM_203292 NM_001081223 NM_001252495 NM_175458 RefSeq (protein) NP_002885 NP_976036 NP_976037 NP_002885.1 NP_976036.1 NP_001074692 NP_001239424 Location (UCSC) Chr 18: 22.8 – 23.03 Mb Chr 18: 11.77 – 11.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinoblastoma ...

  5. Retinoblastoma protein - Wikipedia

    en.wikipedia.org/wiki/Retinoblastoma_protein

    The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide.

  6. RBBP7 - Wikipedia

    en.wikipedia.org/wiki/RBBP7

    5931 245688 Ensembl ENSG00000102054 ENSMUSG00000031353 UniProt Q16576 Q60973 RefSeq (mRNA) NM_001198719 NM_002893 NM_009031 RefSeq (protein) NP_001185648 NP_002884 NP_033057 Location (UCSC) Chr X: 16.84 – 16.87 Mb Chr X: 161.54 – 161.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene. Function ...

  7. Two-hit hypothesis - Wikipedia

    en.wikipedia.org/wiki/Two-hit_hypothesis

    In non-inherited retinoblastoma, instead two mutations, or "hits", had to take place before a tumor could develop, explaining the later onset. It was later found that carcinogenesis (the development of cancer) depended both on the mutation of proto-oncogenes (genes that stimulate cell proliferation ) and on the inactivation of tumor suppressor ...

  8. Retinoblastoma-like protein 1 - Wikipedia

    en.wikipedia.org/wiki/Retinoblastoma-like_protein_1

    The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 gene.The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle.

  9. Eye neoplasm - Wikipedia

    en.wikipedia.org/wiki/Eye_neoplasm

    Retinoblastoma - Strabismus (crossed eyes), a whitish or yellowish glow through the pupil, decreasing/loss of vision, sometimes the eye may be red and painful. Retinoblastoma can occur in one or both eyes. This tumor occurs in babies and young children. It is called RB for short.