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In the field of molecular biology, the ETS (E26 transformation-specific [2] or Erythroblast Transformation Specific [3]) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans, [4] 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila.
ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene. [ 5 ] [ 6 ] The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily.
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene.
ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. [5] Elk-1 functions as a transcription activator . It is classified as a ternary complex factor (TCF), a subclass of the ETS family , which is characterized by a common protein domain that regulates DNA binding to target sequences.
ERG (ETS-related gene) is an oncogene. [ 5 ] [ 6 ] [ 7 ] ERG is a member of the ETS (erythroblast transformation-specific) family of transcription factors. [ 8 ] The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator.
The human ETV6 protein is a member of the ETS transcription factor family; however, it more often acts to inhibit than stimulate transcription of its target genes.ETV6 protein contains 3 domains: a) the pointed N-terminal (i.e. PNT) domain which forms oligomer partners with itself as well as other transcription factors (e.g. FLI1) and is required for ETV6's transcriptional repressing activity ...
Print/export Download as PDF; Printable version; In other projects ... ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene. [5] [6]
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. [6] The nuclear protein binds to a purine-rich sequence known as the PU-box found on enhancers of target genes, and regulates their expression in coordination with other transcription factors and cofactors.