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2. Pioglitazone - Wikipedia

   en.wikipedia.org/wiki/Pioglitazone

   Pioglitazone is used to lower blood glucose levels in type 2 diabetes either alone or in combination with sulfonylurea, metformin, or insulin. [1] The effects of pioglitazone have been compared in a Cochrane systematic review to that of other blood sugar lowering-medicine, including metformin, acarbose, and repaglinide, as well as with appropriate diet and exercise, not showing any benefit in ...

3. Pioglitazone/glimepiride - Wikipedia

   en.wikipedia.org/wiki/Pioglitazone/glimepiride

   [2] [1] It contains the thiazolidinedione pioglitazone and the sulfonylurea glimepiride. [2] [1] It is taken by mouth. [2] [1] The most common side effects include upper respiratory tract infections (such as colds), hypoesthesia (reduced sense of touch), bone fractures, weight gain, dizziness, flatulence (gas) and edema (swelling). [1]

4. Thiazolidinedione - Wikipedia

   en.wikipedia.org/wiki/Thiazolidinedione

   Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):

5. Pioglitazone/metformin - Wikipedia

   en.wikipedia.org/wiki/Pioglitazone/metformin

   The most common side-effects are upper respiratory tract infection, diarrhea, combined edema/peripheral edema and headache, respectively. Most clinical adverse events were similar between groups treated with pioglitazone in combination with metformin and those treated with pioglitazone monotherapy. [medical citation needed]

6. Lexapro: Everything You Need to Know About Its Side Effects - AOL

   www.aol.com/lexapro-everything-know-side-effects...

   Due to its side effects, amitriptyline isn’t commonly used as a first-line treatment for depression. Viorel Kurnosov/istockphoto Another well-known TCA is doxepin, sold under the name Silenor.

7. Management of depression - Wikipedia

   en.wikipedia.org/wiki/Management_of_depression

   The risk factors [110] for treatment resistant depression are: the duration of the episode of depression, severity of the episode, if bipolar, lack of improvement in symptoms within the first couple of treatment weeks, anxious or avoidant and borderline comorbidity and old age. Treatment resistant depression is best handled with a combination ...