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  2. Pharmacodynamics of spironolactone - Wikipedia

    en.wikipedia.org/wiki/Pharmacodynamics_of_spiro...

    The AR antagonism of spironolactone mostly underlies its antiandrogenic activity and is the major mechanism responsible for its therapeutic benefits in the treatment of androgen-dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women.

  3. Hydrocortisone - Wikipedia

    en.wikipedia.org/wiki/Hydrocortisone

    Hydrocortisone is the pharmaceutical term for cortisol used in oral administration, intravenous injection, or topical application.It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients needing steroid treatment but unable to take oral medication, and perioperatively in ...

  4. Spironolactone - Wikipedia

    en.wikipedia.org/wiki/Spironolactone

    Response to treatment generally requires 1 to 3 months in the case of acne and up to 6 months in the case of hirsutism. [67] Ongoing therapy is generally required to avoid relapse of symptoms. [67] Spironolactone is commonly used in the treatment of hirsutism in women, and is considered to be a first-line antiandrogen for this indication. [68]

  5. 11-Deoxycorticosterone - Wikipedia

    en.wikipedia.org/wiki/11-Deoxycorticosterone

    11-Deoxycorticosterone (DOC), or simply deoxycorticosterone, also known as 21-hydroxyprogesterone, as well as desoxycortone (), deoxycortone, and cortexone, [1] [2] is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. [3]

  6. Metyrapone - Wikipedia

    en.wikipedia.org/wiki/Metyrapone

    It is not for long term definitive treatment/cure, only as an adjunct (surgery is the aim for cure in most causes of Cushing's syndrome). Metyrapone hence acts by inhibiting adrenal steroidogenesis. One side effect is hirsutism (in women) because of the excess androgen precursors created.

  7. Prednisolone - Wikipedia

    en.wikipedia.org/wiki/Prednisolone

    Prednisolone is a synthetic pregnane corticosteroid closely related to its cognate prednisone, having identical structure save for two fewer hydrogens near C 11. It is also known as δ 1 -cortisol , δ 1 -hydrocortisone , 1,2-dehydrocortisol , or 1,2-dehydrohydrocortisone , as well as 11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione .

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