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Necrotizing fasciitis (NF), also known as flesh-eating disease, is an infection that kills the body's soft tissue. [3] It is a serious disease that begins and spreads quickly. [ 3 ] Symptoms include red or purple or black skin, swelling, severe pain, fever , and vomiting. [ 3 ]
Fournier gangrene is usually diagnosed clinically, but laboratory tests and imaging studies are used to confirm diagnosis, determine severity, and predict outcomes. [2] X-rays and ultrasounds may show the presence of gas below the surface of the skin. [2] A CT scan can be useful in determining the site of origin and extent of spread. [2]
Fournier gangrene is a type of necrotizing fasciitis that usually affects the genitals and groin. [27] Venous limb gangrene may be caused by Heparin-induced thrombocytopenia and thrombosis. [28] Severe mesenteric ischemia may result in gangrene of the small intestine. [citation needed] Severe ischemic colitis may result in gangrene of the large ...
Necrotizing fasciitis [1] Compartment syndrome [2] Mesenteric ischemia [3] Mueller-Weiss disease [4] Also used in reference to the medical diagnosis of Malingering ICD-10 Z76.5 as in "Pain out of proportion to symptoms". [5]
The affected tissue of patients with severe cases of necrotizing fasciitis are devoid of neutrophils. [27] The serine protease ScpC, which is released by S. pyogenes, is responsible for preventing the migration of neutrophils to the spreading infection. ScpC degrades the chemokine IL-8, which would otherwise attract neutrophils to the site of ...
Fasciitis is an inflammation of the fascia, [1] which is the connective tissue surrounding muscles, blood vessels and nerves. In particular, it often involves one of the following diseases: Necrotizing fasciitis
Diagnosis is by a swab of the affected area for laboratory testing. A Gram stain is performed to show Gram-positive cocci in chains. Then, the organism is cultured on blood agar. The rapid pyrrolidonyl arylamidase (PYR) test is commonly used, wherein a positive reaction confers a presumptive identification of group A beta-hemolytic streptococci ...
Infection may vary in the depth of tissue to which it extends. Foot infections range from the most superficial, cellulitis, to deeper soft tissue necrotizing fasciitis, which may necessitate limb amputations or become life-threatening. [9] [10] [11] Infections may also extend to bone, termed osteomyelitis.