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Because many organs can be affected by myeloma, the symptoms and signs vary greatly. Fatigue and bone pain are the most common symptoms at presentation. The CRAB criteria were formerly the benchmark used to establish the presence of active multiple myeloma (as opposed to an earlier, generally asymptomatic, "smoldering" form of the disease).
Other areas of concentration include bone marrow transplants, stem cell transplantation, lymphoma, leukemia, multiple myeloma, neuro-oncology, cutaneous malignancy, gastrointestinal, geriatric, head and neck, thoracic, urologic, breast, and gynecologic. [2] As of 2023, Andre Goy is chair and Chief Physician Officer. [3] [4] [5]
The underlying cause of MIDD is the production of monoclonal immunoglobulins. Monoclonal immunoglobulins are produced in diseases that feature abnormal proliferation of plasma cells. These diseases include monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, multiple myeloma and Waldenström's macroglobulinemia.
What is multiple myeloma? Multiple myeloma is a cancer of plasma cells, which are found in the bone marrow and are an important part of the immune system, according to the American Cancer Society .
Sagar Lonial – Hematologist specializing in multiple myeloma. Chief Medical Officer of Winship Cancer Institute. [12] Reshma Jagsi - Radiation oncologist and expert in breast cancer and bioethics research. Chair of Radiation Oncology. [13] Rafi Ahmed – Virologist and immunologist. Co-Leader of the Cancer Immunology Program.
Many of the signs and symptoms in POEMS syndrome are due at least in part to the release of an aberrant immunoglobulin, i.e. a myeloma protein, as well as certain cytokines by the malignant plasma cells. [9] [3] [4] POEMS syndrome typically begins in middle age – the average age at onset is 50 – and affects up to twice as many men as women.
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