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Intergenic (also known as extragenic) suppression relieves the effects of a mutation in one gene by a mutation somewhere else within the genome. The second mutation is not on the same gene as the original mutation. [2] Intergenic suppression is useful for identifying and studying interactions between molecules, such as proteins. For example, a ...
In general terms, mutations in silencer elements or regions could lead to either the inhibition of the silencer's action or to the persisting repression of a necessary gene. This can then lead to the expression or suppression of an undesired phenotype which may affect the normal functionality of certain systems in the organism.
Reproductive suppression is the prevention or inhibition of reproduction in otherwise healthy adult individuals. It occurs in birds, mammals, and social insects . It is sometimes accompanied by cooperative breeding .
Gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene. [1] [2] Gene silencing can occur during either transcription or translation and is often used in research.
RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Historically, RNAi was known by other names, including co-suppression, post-transcriptional gene silencing (PTGS), and quelling. The ...
The critical role regulatory T cells play within the immune system is evidenced by the severe autoimmune syndrome that results from a genetic deficiency in regulatory T cells (IPEX syndrome – see also below). Diagram of regulatory T cell, effector T cells and dendritic cell showing putative mechanisms of suppression by regulatory T cells.
Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions. [1] [2]
Fire suppression system. Firefighting, involves the suppression of fire; Free energy suppression and other suppressed technology; Silence suppression, in telephony; Transient-voltage-suppression diode, an electronic component used to protect sensitive electronics from voltage spikes induced on connected wires