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The spindle checkpoint, or SAC (for spindle assembly checkpoint), also known as the mitotic checkpoint, is a cellular mechanism responsible for detection of: correct assembly of the mitotic spindle; attachment of all chromosomes to the mitotic spindle in a bipolar manner; congression of all chromosomes at the metaphase plate.
It is referred to as the mitotic spindle during mitosis, a process that produces genetically identical daughter cells, or the meiotic spindle during meiosis, a process that produces gametes with half the number of chromosomes of the parent cell. Besides chromosomes, the spindle apparatus is composed of hundreds of proteins.
The thick lines are chromosomes, and the thin blue lines are fibers pulling on the chromosomes and pushing the ends of the cell apart. The cell cycle in eukaryotes: I = Interphase, M = Mitosis, G 0 = Gap 0, G 1 = Gap 1, G 2 = Gap 2, S = Synthesis, G 3 = Gap 3. Cell division is the process by which a parent cell divides into two daughter cells. [1]
The spindle checkpoint, also known as the metaphase-to-anaphase transition, the spindle assembly checkpoint (SAC), the metaphase checkpoint, or the mitotic checkpoint, is a cell cycle checkpoint during metaphase of mitosis or meiosis that prevents the separation of the duplicated chromosomes until each chromosome is properly attached to the ...
A type Ia sensory fiber, or a primary afferent fiber, is a type of afferent nerve fiber. [1] It is the sensory fiber of a stretch receptor called the muscle spindle found in muscles, which constantly monitors the rate at which a muscle stretch changes. The information carried by type Ia fibers contributes to the sense of proprioception.
Interphase is the active portion of the cell cycle that includes the G1, S, and G2 phases, where the cell grows, replicates its DNA, and prepares for mitosis, respectively. Interphase was formerly called the " resting phase ," but the cell in interphase is not simply dormant .
The motor part of the spindle is provided by motor neurons: up to a dozen gamma motor neurons also known as fusimotor neurons. [4] These activate the muscle fibres within the spindle. Gamma motor neurons supply only muscle fibres within the spindle, whereas beta motor neurons supply muscle fibres both within and outside of the spindle.
Type Aα fibers include the type Ia and type Ib sensory fibers of the alternative classification system, and are the fibers from muscle spindle endings and the Golgi tendon, respectively. [1] Type Aβ fibres, and type Aγ, are the type II afferent fibers from stretch receptors. [1] Type Aβ fibres from the skin are mostly dedicated to touch.