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GLP-1 Diet Plan. GLP-1 medications — that’s glucagon-like peptide-1 receptor agonists — are prescribed alongside diet and exercise to help people lose weight or manage type 2 diabetes. But ...
Good candidates for using GLP-1 for weight loss have a body mass index (BMI) of 30 kg/m2 or higher. BMI is a measure of body fat. For reference, a healthy BMI range is 18.5 to 24.9 kg/m2.
Yes, GLP-1 medications like Wegovy, Zepbound and Mounjaro have been approved for weight loss in individuals without diabetes who meet specific criteria, such as those with obesity or certain ...
Tirzepatide, a dual agonist of GLP-1 and GIP receptors, is approved for type 2 diabetes and obesity. With an average 20 percent weight loss at a high dosage, it appears to be more effective than GLP-1 mono agonists although there have been no head to head trials as of 2023. [1] [3]
GLP-1 agonists are recommended as an add-on therapy to lifestyle intervention (calorie restriction and exercise) in people with a BMI over 30 or a BMI over 27 with at least one weight-related comorbidity. [13] Some GLP-1 agonists, such as semaglutide, are more effective than other weight loss drugs, but are still less effective than bariatric ...
The initial product GLP-1 (1–37) is susceptible to amidation and proteolytic cleavage, which gives rise to the two truncated and equipotent biologically active forms, GLP-1 (7–36) amide and GLP-1 (7–37). Active GLP-1 protein secondary structure includes two α-helices from amino acid position 13–20 and 24–35 separated by a linker region.