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Parathion, also called parathion-ethyl or diethyl parathion, is an organophosphate insecticide and acaricide.It was originally developed by IG Farben in the 1940s. It is highly toxic to non-target organisms, including humans, so its use has been banned or restricted in most countries.
Year of discovery Name of the drug Year when the synthesis mechanism was developed Year that was Patented Governmental approval Patented expiry Drug type * 2000: Bevacizumab: 2004: 2024 MA 2001: Valdecoxib: 2016: N/A SM 2001: Etoricoxib: 2016: N/A SM 2003: Alirocumab: 2015: 2035 MA 2006: Linagliptin: 2011 [31] 2031 SM 2007: Apixaban: 2012: 2032 ...
Parathion methyl, or methyl parathion, is an organophosphate insecticide, possessing an organothiophosphate group. It is structurally very similar to parathion-ethyl . It is not allowed for sale and import in nearly all countries around the world, while a few allow it under subject to specified conditions only.
An oocyte (/ ˈ oʊ ə s aɪ t /, oöcyte, or ovocyte is a female gametocyte or germ cell involved in reproduction.In other words, it is an immature ovum, or egg cell.An oocyte is produced in a female fetus in the ovary during female gametogenesis.
Scheme showing analogies in the process of maturation of the ovum and the development of the spermatids. A gametocyte is a eukaryotic germ cell that divides by mitosis into other gametocytes or by meiosis into gametids during gametogenesis.
1911 - 1990s According to the FDA's Timeline of Selected FDA Activities and Significant Events Addressing Opioid Misuse and Abuse, before the 1990s, most opioid pain medications were used to manage pain that was either acute or related to cancer. The FDA said that there was an increase in the use of opioids because physicians were not treating ...
Most oogonia have either degenerated or differentiated into primary oocytes by birth. [3] [5] Primary oocytes will undergo oogenesis in which they enter meiosis. However, primary oocytes are arrested in prophase 1 of the first meiosis and remain in that arrested stage until puberty begins in the female adult. [6]
The structure-activity relationship of the drug class has been explored to a reasonable extent. The optimal substitution pattern is fairly tightly defined (i.e. N,N-diethyl on the amine nitrogen, 4-ethoxy on the benzyl ring and 5-nitro on the benzimidazole ring), but even derivatives incorporating only some of these features are still potent opioids.