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Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
Several things can cause a high PSA, including prostatitis, benign prostate enlargement, or prostate cancer, Dr. Pohlman says. ... The two grades are added together to come up with the Gleason score.
On his doctor’s urging, Steves had taken a prostate-specific antigen blood test (PSA) for the first time ever. “That probably saved my life,” he says. “That probably saved my life,” he says.
If the examination suggests anomalies, a PSA test is performed. If an elevated PSA level is found, a follow-up test is then performed. [2] A 2018 review recommended against primary care screening for prostate cancer with DRE due to the lack of evidence of the effectiveness of the practice. [23]
After either treatment, PSA levels are monitored regularly. Up to half of those treated will eventually have a rise in PSA levels, suggesting the tumor or small metastases are growing again. [54] People with high or rising PSA levels are often offered another round of radiation therapy directed at the former tumor site.
However, checking blood PSA levels for prostate cancer screening is controversial and not necessarily indicated in every evaluation for BPH. [2] Benign prostatic hyperplasia and prostate cancer are both capable of increasing blood PSA levels and PSA elevation is unable to differentiate these two conditions well. [2]
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PSA screening is controversial as PSA may become elevated due to non-cancerous conditions such as benign prostatic hyperplasia (BPH), by infection, or by manipulation of the prostate during surgery or catheterization. Additionally many prostate cancers detected by screening develop so slowly that they would not cause problems during a man's ...