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The yardstick for human mortality from H5N1 is the case-fatality rate (CFR); the ratio of the number of confirmed human deaths resulting from infection of H5N1 to the number of those confirmed cases of infection with the virus. For example, if there are 100 confirmed cases of a disease and 50 die as a consequence, then the CFR is 50%.
Between 2003 and November 2024, the World Health Organization has recorded 948 cases of confirmed H5N1 influenza, leading to 464 deaths. [6] The true fatality rate may be lower because some cases with mild symptoms may not have been identified as H5N1. [7]
Human infectious diseases may be characterized by their case fatality rate (CFR), the proportion of people diagnosed with a disease who die from it (cf. mortality rate).It should not be confused with the infection fatality rate (IFR), the estimated proportion of people infected by a disease-causing agent, including asymptomatic and undiagnosed infections, who die from the disease.
A human case of H5N1 was reported in the U.S. in April, "though this detection may have been the result of contamination of the nasal passages with the virus rather than actual infection." [1] [18] In September, Spain reported a human case; this was followed by a second case in November, in a person who worked at the same poultry farm as the ...
Influenza mortality in symptomatic cases in the US for the 2018/2019 season [66] Influenza is typically characterized by seasonal epidemics and sporadic pandemics. Most of the burden of influenza is a result of flu seasons caused by influenza A virus and influenza B virus.
Case fatality was high in all age groups but was highest in persons aged 10 to 39 years. The case-fatality profile by age group differs from that seen in seasonal influenza, where mortality is highest in the elderly. The overall case-fatality rate was highest in 2004 (73%), followed by 63% to date in 2006, and 43% in 2005.
The following is a list of the causes of human deaths worldwide for different years arranged by their associated mortality rates. In 2002, there were about 57 million deaths. In 2005, according to the World Health Organization (WHO) using the International Classification of Diseases (ICD), about 58 million people died. [1]
Historically, measures of influenza pandemic severity were based on the case fatality rate. [6] However, the case fatality rate might not be an adequate measure of pandemic severity during a pandemic response because: [2] Deaths may lag several weeks behind cases, making the case fatality rate an underestimate