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Bavituximab is an antibody that binds to complexes of the phosphatidylserine-binding plasma protein β2-glycoprotein 1 and anionic phospholipids. In laboratory experiments, treatment with bavituximab was found to rescue mice from otherwise lethal infections of mouse cytomegalovirus (CMV), and Pichinde virus, a model of Lassa fever virus .
Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane. [1] It plays a key role in cell cycle signaling, specifically in relation to apoptosis . It is a key pathway for viruses to enter cells via apoptotic mimicry . [ 2 ]
19210 Ensembl ENSG00000156471 ENSMUSG00000021518 UniProt P48651 Q99LH2 RefSeq (mRNA) NM_014754 NM_001290225 NM_008959 RefSeq (protein) NP_001277154 NP_055569 NP_032985 Location (UCSC) Chr 8: 96.26 – 96.34 Mb Chr 13: 67.08 – 67.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phosphatidylserine synthase 1 is a protein that in humans is encoded by the PTDSS1 gene. Function The ...
non-small cell lung cancer: Anatumomab mafenatox [17] Fab: mouse: Tumor-associated glycoprotein 72 (TAG-72) non-small cell lung cancer: Andecaliximab [18] mab: chimeric: gelatinase B: gastric cancer or gastroesophageal junction adenocarcinoma Anetumab ravtansine [4] mab: human: mesothelin (MSLN) cancer Anifrolumab [4] Saphnelo: mab: human: IFN ...
CT scan or kidney ultrasonography is useful in the diagnosis of xanthogranulomatous pyelonephritis; serial imaging may be useful for differentiating this condition from kidney cancer. [ 10 ] Acute pyelonephritis with increased cortical echogenicity and blurred delineation of the upper pole [ 20 ]
[45] [46] Moreover, the lifetime incidence of breast cancer in men is approximately 0.1%, [47] the average age of diagnosis of prostate cancer and male breast cancer are similar (around 70 years), [10] [48] and millions of men have been treated with bicalutamide for prostate cancer, [49] all of which are potentially in support of the notion of ...
Prostate cancer is the development of cancer in the prostate, a gland in the male reproductive system. [27] Most prostate cancers are slow growing; however, some grow relatively quickly. [28] [29] The cancer cells may spread from the prostate to other areas of the body, particularly the bones and lymph nodes. [30] It may initially cause no ...
The remaining unbound arsenic (≤ 10%) accumulates in cells, which over time may lead to skin, bladder, kidney, liver, lung, and prostate cancers. [71] Other forms of arsenic toxicity in humans have been observed in blood, bone marrow, cardiac, central nervous system, gastrointestinal, gonadal, kidney, liver, pancreatic, and skin tissues.