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Chromosome decondensation (also known as relaxation or decompaction) into expanded chromatin is necessary for the cell's resumption of interphase processes, and occurs in parallel to nuclear envelope assembly during telophase in many eukaryotes. [2] MEN-mediated Cdk dephosphorylation is necessary for chromosome decondensation. [2] [5]
Chromosome scaffold has important role to hold the chromatin into compact chromosome. Chromosome scaffold is made of proteins including condensin, topoisomerase IIα and kinesin family member 4 (KIF4) [7] Dinoflagellates are very divergent eukaryotes in terms of how they package their DNA. Their chromosomes are packed in a liquid-crystalline ...
The process ends with telophase II, which is similar to telophase I, and is marked by decondensation and lengthening of the chromosomes and the disassembly of the spindle. Nuclear envelopes re-form and cleavage or cell plate formation eventually produces a total of four daughter cells, each with a haploid set of chromosomes.
Chromosome scaffolds play an important role to hold the chromatin into compact chromosomes. Loops of 30 nm structure further condense with scaffold, into higher order structures. [ 21 ] Chromosome scaffolds are made of proteins including condensin , type IIA topoisomerase and kinesin family member 4 (KIF4). [ 22 ]
RNF8 mediates extensive chromatin decondensation, through its subsequent interaction with CHD4 protein, [22] a component of the nucleosome remodeling and deacetylase complex NuRD. CHD4 accumulation at the site of the double-strand break is rapid, with half-maximum accumulation occurring by 40 seconds after irradiation. [23]
This is an accepted version of this page This is the latest accepted revision, reviewed on 8 February 2025. DNA molecule containing genetic material of a cell This article is about the DNA molecule. For the genetic algorithm, see Chromosome (genetic algorithm). Chromosome (10 7 - 10 10 bp) DNA Gene (10 3 - 10 6 bp) Function A chromosome and its packaged long strand of DNA unraveled. The DNA's ...
Premature chromosome condensation (PCC), also known as premature mitosis, occurs in eukaryotic organisms when mitotic cells fuse with interphase cells. [1] Chromatin , a substance that contains genetic material such as DNA , is normally found in a loose bundle inside a cell's nucleus.
In biology, the chromosome scaffold is the backbone that supports the structure of the chromosomes. It is composed of a group of non-histone proteins that are essential in the structure and maintenance of eukaryotic chromosomes throughout the cell cycle. These scaffold proteins are responsible for the condensation of chromatin during mitosis. [1]