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Touton giant cells are also referred to as xanthelasmatic cells due to the fact they are found in lesions associated with xanthomas which are skin growths with yellow, lipid filled deposits. Touton giant cells are often frequently observed in granulomatous inflammation, which is a type of inflammation caused by the clustering of immune cells ...
Also known as xanthelasmatic giant cells, Touton giant cells consist of fused epithelioid macrophages and have multiple nuclei. They are characterized by the ring-shaped arrangement of their nuclei and the presence of foamy cytoplasm surrounding the nucleus. Touton giant cells have been observed in lipid-laden lesions such as fat necrosis.
Histopathology of juvenile xanthogranuloma characteristiclaly shows scattered Touton giant cells. [6] Ocular JXG manifests in up to 10% of people with JXG and may affect their vision. [3] The presence of JXG in the eye can cause spontaneous hyphema, secondary glaucoma or even blindness.
Touton type giant cells and foamy cells VI. Tumoral lesions: Benign tumoral lesions Mastocytoma: Abundant mast cells Tzanck smear test is useful for rapid diagnosis of mastocytoma in children Sebaceous hyperplasia: Clusters of sebocytes Seborrheic keratosis: Hyperkeratosis and horny cysts 87.5% sensitive and 80.8% specific Melanocytic nevi
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Specific forms of multinucleated giant cells include the Touton giant cell, which contains a ring of nuclei surrounding a central homogeneous cytoplasm, with foamy cytoplasm surrounding the nuclei. [ 29 ] [ 30 ] The central cytoplasm (surrounded by the nuclei) may be both amphophilic and eosinophilic.
Pluto likely acquired large moon Charon in a “kiss and capture” collision billions of years ago. It may have created a subsurface ocean on the icy dwarf planet.
Granulation tissue with a poorly formed granuloma to the left of centre. Within this area there is a multinucleate giant cell of the Langhans type. The patient had a healing mycobacterial infection of the skin (Mycobacterium ulcerans infection). Langhans giant cells (LGC) are giant cells found in granulomatous conditions.