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The 4Kscore combines total, free and intact PSA together with human kallikrein 2. [46] It is used to try to determine the risk of a Gleason score greater than 6. [46] The Prostate Health Index (PHI) is a PSA-based blood test for early prostate cancer screening. It may be used to determine when a biopsy is needed.
He was responsible for designing the algorithm [8] that is used in the commercial "4Kscore" test [9] for men with elevated PSA. With colleague Hans Lilja, Vickers published a series of studies demonstrating that a single PSA at age 45 - 60 is an extremely strong predictor of the long-term risk of prostate cancer mortality.
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OPKO Health Announces Launch of 4Kscore™ in Europe Strategic Partner, International Health Technology Ltd, Launches Laboratory Service MIAMI--(BUSINESS WIRE)-- OPKO Health, Inc. (NYSE:OPK) today ...
In statistics, intra-rater reliability is the degree of agreement among repeated administrations of a diagnostic test performed by a single rater. [ 1 ] [ 2 ] Intra-rater reliability and inter-rater reliability are aspects of test validity .
Kappa is a way of measuring agreement or reliability, correcting for how often ratings might agree by chance. Cohen's kappa, [ 5 ] which works for two raters, and Fleiss' kappa, [ 6 ] an adaptation that works for any fixed number of raters, improve upon the joint probability in that they take into account the amount of agreement that could be ...
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Cohen's kappa measures the agreement between two raters who each classify N items into C mutually exclusive categories. The definition of is =, where p o is the relative observed agreement among raters, and p e is the hypothetical probability of chance agreement, using the observed data to calculate the probabilities of each observer randomly selecting each category.