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The 4Kscore combines total, free and intact PSA together with human kallikrein 2. [46] It is used to try to determine the risk of a Gleason score greater than 6. [46] The Prostate Health Index (PHI) is a PSA-based blood test for early prostate cancer screening. It may be used to determine when a biopsy is needed.
He was responsible for designing the algorithm [8] that is used in the commercial "4Kscore" test [9] for men with elevated PSA. With colleague Hans Lilja, Vickers published a series of studies demonstrating that a single PSA at age 45 - 60 is an extremely strong predictor of the long-term risk of prostate cancer mortality.
Cohen's kappa measures the agreement between two raters who each classify N items into C mutually exclusive categories. The definition of is =, where p o is the relative observed agreement among raters, and p e is the hypothetical probability of chance agreement, using the observed data to calculate the probabilities of each observer randomly selecting each category.
The 4Kscore test provides an individual's probability score of finding aggressive prostate cancer defined as a Gleason Score equal or greater than seven prior to a biopsy decision.
OPKO Health Announces Launch of 4Kscore™ in Europe Strategic Partner, International Health Technology Ltd, Launches Laboratory Service MIAMI--(BUSINESS WIRE)-- OPKO Health, Inc. (NYSE:OPK) today ...
The log diagnostic odds ratio is sometimes used in meta-analyses of diagnostic test accuracy studies due to its simplicity (being approximately normally distributed). [ 4 ] Traditional meta-analytic techniques such as inverse-variance weighting can be used to combine log diagnostic odds ratios computed from a number of data sources to produce ...
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Statistical packages can calculate a standard score (Z-score) for Cohen's kappa or Fleiss's Kappa, which can be converted into a P-value. However, even when the P value reaches the threshold of statistical significance (typically less than 0.05), it only indicates that the agreement between raters is significantly better than would be expected ...