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Monocytopenia is a form of leukopenia associated with a deficiency of monocytes. It has been proposed as a measure during chemotherapy to predict neutropenia , [ 1 ] though some research indicates that it is less effective than lymphopenia .
Infectious mononucleosis (IM, mono), also known as glandular fever, is an infection usually caused by the Epstein–Barr virus (EBV). [2] [3] Most people are infected by the virus as children, when the disease produces few or no symptoms. [2]
Monocytosis is an increase in the number of monocytes circulating in the blood. [1] Monocytes are white blood cells that give rise to macrophages and dendritic cells in the immune system. In humans, monocytosis occurs when there is a sustained rise in monocyte counts greater than 800/mm 3 to 1000/mm 3. [2]
A white blood cell differential is a medical laboratory test that provides information about the types and amounts of white blood cells in a person's blood. The test, which is usually ordered as part of a complete blood count (CBC), measures the amounts of the five normal white blood cell types – neutrophils, lymphocytes, monocytes, eosinophils and basophils – as well as abnormal cell ...
Pancytopenia is a medical condition in which there is significant reduction in the number of almost all blood cells (red blood cells, white blood cells, platelets, monocytes, lymphocytes, etc.). If only two parameters from the complete blood count are low, the term bicytopenia can be used. The diagnostic approach is the same as for pancytopenia.
CMML-2 has a reduced overall survival as compared with CMML-1, with median survivals of 15 and 20 months, respectively. Myeloproliferative CMML (>13x10 9 monocytes/L) has a reduced survival compared with myelodysplastic CMML. A platelet count of <100 x10 9 /L reduces overall survival. A haemoglobin level of <10g/dL has a reduced overall survival.
A high count of CD14 + CD16 ++ monocytes is found in severe infection . [30] In the field of atherosclerosis, high numbers of the CD14 ++ CD16 + intermediate monocytes were shown to be predictive of cardiovascular events in populations at risk. [31] [32] CMML is characterized by a persistent monocyte count of > 1000/microL of blood.
Acute monocytic leukemia (AMoL, or AML-M5) [2] is a type of acute myeloid leukemia.In AML-M5 >80% of the leukemic cells are of monocytic lineage. [3] This cancer is characterized by a dominance of monocytes in the bone marrow.