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All clinical experience with NCT to date is with boron-10; hence this method is known as boron neutron capture therapy (BNCT). [1] Use of another non-radioactive isotope, such as gadolinium, has been limited to experimental animal studies and has not been done clinically.
Neutron capture therapy was first proposed in the literature in 1936 by Gordon L. Locher, who observed that isotopes with large neutron capture cross sections, such as boron-10, could be accumulated in cancerous tissue and bombarded with thermal neutrons to induce destruction of the cancerous cells. [4]
Each salient feature of the reactor was designed in relation to its use for therapy and diagnosis or in the advancement of basic medical science.” [3] One of the treatments pioneered at this reactor was boron neutron capture therapy, or BNCT. This promising treatment was developed for use against glioblastoma multiforme, an otherwise ...
Enriched boron or 10 B is used in both radiation shielding and is the primary nuclide used in neutron capture therapy of cancer. In the latter ("boron neutron capture therapy" or BNCT), a compound containing 10 B is incorporated into a pharmaceutical which is selectively taken up by a malignant tumor and tissues near it. The patient is then ...
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Neutron capture is a nuclear reaction in which an atomic nucleus and one or more neutrons collide and merge to form a heavier nucleus. [1] Since neutrons have no electric charge, they can enter a nucleus more easily than positively charged protons , which are repelled electrostatically .
Novel therapy methods - accelerator based boron neutron capture therapy of cancer (BNCT) using high therapeutic gain epi-thermal neutrons for malignant tumors therapy. R&D of radiopharmaceuticals - utilization of the high current and high power targets of SARAF for production of new radiopharmaceuticals for therapy and diagnostics.
The role of the boron atom in neutron capture therapy for malignant brain tumors is to target tumor cells selectively. When a non-radioactive boron isotope ( 10 B ) is administered and accumulates in tumor cells, these cells can be selectively destroyed when irradiated with low-energy thermal neutrons.