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2. Naproxen - Wikipedia

   en.wikipedia.org/wiki/Naproxen

   Naproxen's medical uses are related to its mechanism of action as an anti-inflammatory compound. [11] Naproxen is used to treat a variety of inflammatory conditions and symptoms that are due to excessive inflammation, such as pain and fever (naproxen has fever-reducing, or antipyretic, properties in addition to its anti-inflammatory activity). [11]

3. Hepatotoxicity - Wikipedia

   en.wikipedia.org/wiki/Hepatotoxicity

   A group of enzymes located in the endoplasmic reticulum, known as cytochrome P-450, is the most important family of metabolizing enzymes in the liver. Cytochrome P-450 is not a single enzyme, but rather consists of a closely related family of 50 isoforms; six of them metabolize 90% of drugs.

4. Side effects of bicalutamide - Wikipedia

   en.wikipedia.org/wiki/Side_effects_of_bicalutamide

   Rates of elevated liver enzymes have ranged from 2.9 to 11.4% in these studies, which spontaneously resolved in some women and necessitated discontinuation of treatment in others. [ 138 ] [ 139 ] No cases of liver failure or death due to liver toxicity were seen with bicalutamide in the initial clinical development programme for prostate cancer ...

5. Bicalutamide - Wikipedia

   en.wikipedia.org/wiki/Bicalutamide

   [18] [27] Hepatic changes that have necessitated discontinuation of bicalutamide, such as marked increases in liver enzymes or hepatitis, have occurred in 0.3 to 1.5% of men in clinical trials, or approximately 1% overall. [27] [13] [33] [122] [123] Elevated liver enzymes with bicalutamide usually occur within the first 3 to 6 months of treatment.

6. Nimesulide - Wikipedia

   en.wikipedia.org/wiki/Nimesulide

   Less than 10 days of nimesulide does not appear to increase the risk of hypothermia, gastrointestinal bleeding, epigastric pain, vomiting, diarrhea, or transient, asymptomatic elevation of liver enzymes compared to ketoprofen, paracetamol, mefenamic acid, aspirin, or ibuprofen in children. However, data does not speak to populations less than 6 ...

7. CYP2C9 - Wikipedia

   en.wikipedia.org/wiki/CYP2C9

   CYP2C9 is a crucial cytochrome P450 enzyme, which plays a significant role in the metabolism, by oxidation, of both xenobiotic and endogenous compounds. [7] CYP2C9 makes up about 18% of the cytochrome P450 protein in liver microsomes. The protein is mainly expressed in the liver, duodenum, and small intestine. [7]