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But LDL is also essential for carrying lipids that keep the human body alive, including in those small vessels. Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein that transport all fat molecules around the body in extracellular water. [1]
The N-terminal domain of the LDL receptor, which is responsible for ligand binding, is composed of seven sequence repeats (~50% identical). Each repeat, referred to as a class A repeat or LDL-A, contains roughly 40 amino acids, including 6 cysteine residues that form disulfide bonds within the repeat. Additionally, each repeat has highly ...
LDL, the “bad” kind, contributes to fatty buildup in your arteries and heart, putting you at risk for heart attacks, while HDL carries the LDL away from your arteries and back to the liver ...
LDL circulates and is absorbed by the liver and peripheral cells. Binding of LDL to its target tissue occurs through an interaction between the LDL receptor and apolipoprotein B-100 on the LDL particle. Absorption occurs through endocytosis, and the internalized LDL particles are hydrolyzed within lysosomes, releasing lipids, chiefly cholesterol.
High LDL cholesterol is the most common type of dyslipidemia; it’s also known as hyperlipidemia or simply high cholesterol. Hyperlipidemia happens when you have high levels of one or more lipids ...
"Some people, known as hyper-responders, may see a significant increase in their LDL levels when they eat cholesterol," Dr. Jneid says. "However, what matters more for heart health is the type of ...
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