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There are currently two available RSV vaccines approved for use in the U.S. in people over 60, Abrysvo and Arexvy. The latter is also approved for adults aged 50 to 59 who are at an increased risk ...
New RSV vaccines are now available to help prevent serious infection in people over 60. Doctors explain the RSV vaccine and its side effects in older adults.
RSV structure and genome organization. (a) ~150 nm RSV virion particle and (b) single-stranded negative-sense RNA genome consisting of 10 genes (NS1-NS2-N-P-M-SH-G-F-M2-L). RSV has a negative-sense, single-stranded RNA genome. [2] The genome is linear and approximately 15,000 nucleotides in length. [3] It has 10 genes encoding for 11 proteins.
It is similar to DNA but with the replacement of thymine by uracil and the adding of one oxygen atom. [1] Despite the structural similarities, much less is known about dsRNA. [2] They form the genetic material of some viruses (double-stranded RNA viruses). dsRNA, such as viral RNA or siRNA, can trigger RNA interference in eukaryotes, as well as ...
Conventional vaccines contain either specific antigens from a pathogen, or attenuated viruses which stimulate an immune response in the vaccinated organism. DNA vaccines are members of the genetic vaccines, because they contain a genetic information (DNA or RNA) that codes for the cellular production (protein biosynthesis) of an antigen.
Nucleic acid vaccines use mRNA to give cells instructions on how to produce a desired protein. Libre de Droit/iStock via Getty ImagesThe two most successful coronavirus vaccines developed in the U ...
Double-stranded RNA viruses (dsRNA viruses) are a polyphyletic group of viruses that have double-stranded genomes made of ribonucleic acid.The double-stranded genome is used as a template by the viral RNA-dependent RNA polymerase (RdRp) to transcribe a positive-strand RNA functioning as messenger RNA (mRNA) for the host cell's ribosomes, which translate it into viral proteins.
The main types of RNA therapeutics are those based on messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), and RNA aptamers. Of the four types, mRNA-based therapy is the only type which is based on triggering synthesis of proteins within cells, making it particularly useful in vaccine development. [ 3 ]