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Orexin receptor type 2 (Ox2R or OX 2), also known as hypocretin receptor type 2 (HcrtR2), is a protein that in humans is encoded by the HCRTR2 gene. [5] It should not be confused for the protein CD200R1 which shares the alias OX2R but is a distinct, unrelated gene located on the human chromosome 3.
Orexins – dual OX 1 and OX 2 receptor agonists Orexin-A – approximately equipotent at the OX 1 and OX 2 receptors [2] [3] Orexin-B – approximately 5- to 10-fold selectivity for the OX 2 receptor over the OX 1 receptor [2] [3] AEX-5 – selective OX 1 receptor agonist; also a cathepsin H inhibitor and dopamine reuptake inhibitor [11]
Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...
An orexin receptor antagonist, or orexin antagonist, is a drug that inhibits the effect of orexin by acting as a receptor antagonist of one (selective orexin receptor antagonist or SORA) or both (dual orexin receptor antagonis or DORA) of the orexin receptors, OX 1 and OX 2. [1]
Typical rat poison bait station (Germany, 2010) Rodenticides are chemicals made and sold for the purpose of killing rodents.While commonly referred to as "rat poison", rodenticides are also used to kill mice, woodchucks, chipmunks, porcupines, nutria, beavers, [1] and voles. [2]
In the rat bait pellets, mouse bait pellets, place packs, and wedge baits, the active ingredient was brodifacoum, typically at 0.005% concentration. [21] In contrast, earlier d-CON products that used warfarin had 0.5% concentration. [5] In the refillable and disposable bait stations, the active ingredient was diphacinone. [22]