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Alpha-1 adrenergic receptor. alpha-1 (α1) adrenergic receptors are G protein-coupled receptors (GPCRs) associated with the G q heterotrimeric G protein. α 1 -adrenergic receptors are subdivided into three highly homologous subtypes, i.e., α 1A -, α 1B -, and α 1D -adrenergic receptor subtypes. There is no α 1C receptor.
The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) produced by the body, but also many medications like beta blockers, beta-2 (β 2) agonists and alpha-2 (α 2) agonists, which are used to treat high blood ...
The alpha-1A adrenergic receptor (α 1A adrenoreceptor), also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, [5] is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. [6] There is no longer a subtype α 1C receptor. At one time, there was a subtype known as α 1C, but it was found to be ...
Alpha-1 blocker. Alpha-1 blockers (also called alpha-adrenergic blocking agents or alpha-1 antagonists) constitute a variety of drugs that block the effect of catecholamines on alpha-1-adrenergic receptors. They are mainly used to treat benign prostatic hyperplasia (BPH), hypertension and post-traumatic stress disorder. [1]
Receptor. There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.
Alpha-1B adrenergic receptor. The alpha-1B adrenergic receptor (α 1B -adrenoreceptor), also known as ADRA1B, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. [5] The crystal structure of the α 1B -adrenergic receptor has been determined in complex with the inverse agonist (+)-cyclazosin.
Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene. [ 5] GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels.
CHRNA1. Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene. [5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR). The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 ...