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How to define a normal or abnormal nuchal translucency measurement can be difficult. The use of a single millimeter cutoff (such as 2.5 or 3.0 mm) is inappropriate because nuchal translucency measurements normally increases with gestational age (by approximately 15% to 20% per gestational week from 10 to 13 weeks). [10]
Perhaps the most common such test uses a measurement of the nuchal translucency thickness ("NT-test", or "Nuchal Scan"). Although 91% of fetuses affected by Down syndrome exhibit this defect, 5% of fetuses flagged by the test do not have Down syndrome. Ultrasound may also detect fetal organ anomaly.
MeSH E01.370.350.850.865.500 – nuchal translucency measurement MeSH E01.370.350.925 – whole body imaging MeSH E01.370.370 – diagnostic techniques, cardiovascular
An ultrasound showing an embryo measured to have a crown-rump length of 1.67 cm and estimated to have a gestational age of 8 weeks and 1 day. Crown-rump length (CRL) is the measurement of the length of human embryos and fetuses from the top of the head (crown) to the bottom of the buttocks (rump).
Around weeks 11–13, nuchal translucency scan (NT) may be offered which can be combined with blood tests for PAPP-A and beta-hCG, two serum markers that correlate with chromosomal abnormalities, in what is called the First Trimester Combined Test. The results of the blood test are then combined with the NT ultrasound measurements, maternal age ...
Nicolaides has developed methods of (i) screening for premature birth (which is the main cause of perinatal morbidity and mortality) by measurement of cervical length and prevention through the use of vaginal progesterone, [9] (ii) screening for pre-eclampsia (which is one of the main causes of maternal mortality) by measurement of blood flow ...
It is a separate measurement from the biophysical profile. [ 1 ] AFI is the score (expressed in centimetres ) given to the amount of amniotic fluid seen on ultrasonography of a pregnant uterus .
Increased nuchal translucency in a first-trimester ultrasound may indicate the presence of 13q deletion. [6] It is important to follow through with genetic testing because there are many other diseases that have similar clinical manifestations of 13q deletion syndrome.