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They publish WebMD the Magazine, a patient-directed publication distributed bimonthly free of charge to 85 percent of physician waiting rooms. [13] Medscape is a professional portal for physicians and has training materials, a drug database, and clinical information on 30 medical specialty areas and more than 30 physician discussion boards. [14]
In 2000, Medscape merged with MedicaLogic, Inc., another public company. MedicaLogic filed for bankruptcy within 18 months and sold Medscape to WebMD in December 2001. In 2008, Lundberg was terminated by WebMD. The following year the Medscape Journal of Medicine ceased publishing. [4] In January 2013, Eric Topol was named editor-in-chief of ...
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...
[19] [31] For drugs recently sold on the market, drugs have information pages (monographs) that provide information on any potential interaction between a medication and grapefruit juice. [19] Because there is a growing number of medications that are known to interact with citrus, [ 1 ] patients should consult a pharmacist or physician before ...
Lofexidine prolongs the QT interval, which can result in a severe interaction (torsade de pointes) when combined with other drugs that also prolong the QT interval. Patient-specific characteristics that increase the risk for a clinically significant drug-drug interaction include: [9] increasing age; female sex; cardiac disease
Citalopram should not be taken with St John's wort, tryptophan or 5-HTP as the resulting drug interaction could lead to serotonin syndrome. [60] With St John's wort, this may be caused by compounds in the plant extract reducing the efficacy of the hepatic cytochrome P450 enzymes that process citalopram. [ 61 ]
Lamotrigine has fewer drug interactions than many anticonvulsant drugs, although pharmacokinetic interactions with carbamazepine, phenytoin and other hepatic enzyme-inducing medications may shorten half-life. [83] Dose adjustments should be made on clinical response, but monitoring may be of benefit in assessing compliance. [5]
It is conjugated in the kidney for excretion in the urine, where 75% of the drug is excreted, [116] and about 15% is eliminated in feces. [117]: 430 Desmethylmirtazapine is an active metabolite of mirtazapine which is believed to contribute about 3-10% to the drug's overall effects and has a half-life of about 25 hours. [8]