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A glycine reuptake inhibitor (GRI) is a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters (GlyTs). ). Examples of GRIs include bitopertin (RG1678), iclepertin (BI-425809), ORG-24598, ORG-25935, ALX-5407, and sarcosine, which are selective GlyT1 blockers, and ORG-25435 and N-arachidonylglycine, which are selective GlyT2 blo
The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine. GlyR is an ionotropic receptor that produces its effects through chloride currents .
L-687,414 is a glycine-site NMDA receptor antagonist or low-efficacy partial agonist ... The drug has been found to produce ... or antinociceptive effects, [8] [9] ...
ORG-25935, also known as SCH-900435 is a synthetic drug developed by Organon International, which acts as a selective inhibitor of the glycine transporter GlyT-1.In animal tests it reduces alcohol consumption and has analgesic and anticonvulsant effects, but it has mainly been studied for its antipsychotic properties, and in human trials it was shown to effectively counteract the effects of ...
A glycine receptor agonist is a drug which acts as an agonist of the glycine receptor. Examples. Agonists. β-Alanine; D-Alanine;
Nitromemantine utilizes memantine binding site on the NMDA receptor to target the NO x (X= 1 or 2) group for interaction with the S- nitrosylation/redox site external to the memantine binding site. Lengthening the side chains of memantine compensates for the worse drug affinity in the channel associated with the addition of the –ONO 2 group [115]
A glycine receptor antagonist is a drug which acts as an antagonist of the glycine receptor. [1] [2] Examples. Antagonists.
Glycine is a required co-agonist along with glutamate for NMDA receptors. In contrast to the inhibitory role of glycine in the spinal cord, this behaviour is facilitated at the glutamatergic receptors which are excitatory. [41] The LD 50 of glycine is 7930 mg/kg in rats (oral), [42] and it usually causes death by hyperexcitability. [citation ...