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Viruses that contain double-stranded DNA (dsDNA) share the same kind of genetic material as all organisms, and can therefore use the replication enzymes in the host cell nucleus to replicate the viral genome. Many RNA viruses typically replicate in the cytosol, and can directly access the host cell's ribosomes to manufacture viral proteins once ...
Viruses of the flaviviridae Family, such as hepatitis C virus, have developed complex viral mechanisms to rearrange the cell membrane, creating a membranaceous web designed to house viral replication machinery. These viruses utilize endogenous host cell nuclear pore complex proteins to shield viral RNA from Pattern Recognition Receptors by ...
Some viruses can "hide" within a cell, which may mean that they evade the host cell defenses or immune system and may increase the long-term "success" of the virus. This hiding is deemed latency. During this time, the virus does not produce any progeny, it remains inactive until external stimuli—such as light or stress—prompts it to activate.
Negative-strand RNA viruses (−ssRNA viruses) are a group of related viruses that have negative-sense, single-stranded genomes made of ribonucleic acid (RNA). They have genomes that act as complementary strands from which messenger RNA (mRNA) is synthesized by the viral enzyme RNA-dependent RNA polymerase (RdRp). During replication of the ...
Viral disease is the sum of the effects of viral replication on the host and the host's subsequent immune response against the virus. [3] Viruses are able to initiate infection, disperse throughout the body, and replicate due to specific virulence factors. [2] There are several factors that affect pathogenesis.
Viral RdRps were discovered in the early 1960s from studies on mengovirus and polio virus when it was observed that these viruses were not sensitive to actinomycin D, a drug that inhibits cellular DNA-directed RNA synthesis. This lack of sensitivity suggested the action of a virus-specific enzyme that could copy RNA from an RNA template.
(A) The replication of virophages is supposed to occur entirely in the virus factory of its giant virus host, depending on the giant virus expression/replication complex. (B) The concept of satellite virus implicates that the virus initiates the expression and replication of its genome in the nucleus using the host cell machinery and then goes ...
When a virus infects a cell, the virus forces it to make thousands more viruses. It does this by making the cell copy the virus's DNA or RNA, making viral proteins, which all assemble to form new virus particles. [37] There are six basic, overlapping stages in the life cycle of viruses in living cells: [38]