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Mycosis fungoides, also known as Alibert-Bazin syndrome or granuloma fungoides, [1] is the most common form of cutaneous T-cell lymphoma. It generally affects the skin, but may progress internally over time.
The presentation depends if it is mycosis fungoides or Sézary syndrome, the most common, though not the only types. Among the symptoms for the aforementioned types are: enlarged lymph nodes, an enlarged liver and spleen, and non-specific dermatitis. [1]
Sézary disease and mycosis fungoides are cutaneous T-cell lymphomas having a primary manifestation in the skin. [5] The disease's origin is a peripheral CD4+ T-lymphocyte, [ 3 ] although rarer CD8+/CD4- cases have been observed. [ 3 ]
Adult T-cell leukemia/lymphoma (ATL or ATLL) is a rare cancer of the immune system's T-cells [1] [2] [3] caused by human T cell leukemia/lymphotropic virus type 1 (). [4] All ATL cells contain integrated HTLV-1 provirus further supporting that causal role of the virus in the cause of the neoplasm. [4]
The premycotic phase is a phase of mycosis fungoides in which a patient has areas of red, scaly, itchy skin on areas of the body that are usually not exposed to sun. This is early-phase mycosis fungoides, but it is hard to diagnose the rash as mycosis fungoides during this phase. The premycotic phase may last from months to decades.
Radiotherapy is the use of radiation to eradicate cancer. [2] As the electron beams in radiotherapy only penetrate to the level of the dermis , it is a common method of treatment for skin lymphoma which may only occur locally such as Cutaneous T-cell lymphoma, however, it is not recommended for patients with systemic lymphoma conditions.
Pagetoid reticulosis is a very slow progressive variant of mycosis fungoides and is usually localized unlike the latter. [4] Treatment
This is a list of cutaneous conditions associated with internal malignancy; skin markers of internal cancer. [1] It does not include skin infections associated with cancer or cancers that spread to skin. [1] Some have stronger associations with cancers than others. [2]