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5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]
Holland & Barrett, King Street, Hammersmith, London Holland & Barrett International Limited, trading as Holland & Barrett (H&B), is a British-based multinational chain of health food shops with over 1,300 stores in 16 countries, including a substantial presence in the United Kingdom, Republic of Ireland, Netherlands, Belgium, Mainland China, Hong Kong, India, Saudi Arabia, Lithuania and UAE.
TPH1 was first discovered to support serotonin synthesis in 1988 by converting tryptophan into 5-hydroxytryptophan. [6] It was thought that there only was a single TPH gene until 2003. A second form was found in the mouse ( Tph2 ), rat and human brain ( TPH2 ) and the original TPH was then renamed to TPH1.
Tryptophan (symbol Trp or W) [3] is an α-amino acid that is used in the biosynthesis of proteins.Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic beta carbon substituent.
L-Tryptophan, a precursor of serotonin and melatonin and an example of a monoamine precursor.. Monoamine precursors are precursors of monoamines and monoamine neurotransmitters in the body.
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