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Radiation therapy (RT) is in itself painless, but has iatrogenic side effect risks. Many low-dose palliative treatments (for example, radiation therapy to bony metastases) cause minimal or no side effects, although short-term pain flare-up can be experienced in the days following treatment due to oedema compressing nerves in the treated area ...
Stereotactic External-Beam radiation Therapy, sometimes called SBRT is now being used to treat Small Cell Lung Cancer, and Sarcomas that have metastasized to the lungs. The high doses used in thoracic SBRT can sometimes cause adverse effects ranging from mild rib fatigue and transient esophagitis , to fatal events such as pneumonitis or hemorrhage.
Target Theory, often called the “multi hit model” when examining cell radiation, examines how ionizing radiation affects biological cell functions or survival. Target theory shows many different types of models that help to explain the role radiation plays in cell death or injury.
It has also been used with Stereotactic Body Radiation Therapy to assist with the initial set-up and detect intrafraction patient motion throughout treatment. [3] For stereotactic surgery , SGRT allows a frameless system to be used to monitor the surface of the patient within an open-face immobilization mask.
Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation.As the name implies, TBI involves irradiation of the entire body, though in modern practice the lungs are often partially shielded to lower the risk of radiation-induced lung injury.
External beam radiation therapy (EBRT) is a form of radiotherapy that utilizes a high-energy collimated beam of ionizing radiation, from a source outside the body, to target and kill cancer cells. A radiotherapy beam is composed of particles which travel in a consistent direction; each radiotherapy beam consists of one type of particle intended ...
Intraoperative radiation therapy (IORT) is radiation therapy that is administered during surgery directly in the operating room (hence intraoperative). Usually therapeutic levels of radiation are delivered to the tumor bed while the area is exposed during surgery .
Conventional chemotherapeutics are currently being used in conjunction with radiation therapy to increase its effectiveness. Examples include the fluoropyrimidines, gemcitabine and platinum analogs; fluoropyrimidines increase sensitivity by dysregulating S-phase cell cycle checkpoints in tumor cells.