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Allergen immunotherapy, also known as desensitization or hypo-sensitization, is a medical treatment for environmental allergies (such as insect bites) and asthma. [ 1 ] [ 2 ] Immunotherapy involves exposing people to larger and larger amounts of allergens in an attempt to change the immune system's response.
Enzyme potentiated desensitization (EPD), is a treatment for allergies developed in the 1960s by Dr. Leonard M. McEwen in the United Kingdom. EPD uses much lower doses of antigens than conventional desensitization treatment paired with the enzyme β-glucuronidase .
Desensitization, which is a slow process of consuming tiny amounts of the allergenic protein until the body is able to tolerate more significant exposure, results in reduced symptoms or even remission of the allergy in some people and is being explored for treatment of milk allergy. [89] This is called oral immunotherapy (OIT).
In medicine, desensitization is a method to reduce or eliminate an organism's negative reaction to a substance or stimulus. In pharmacology , drug desensitization refers to two related concepts. First, desensitization may be equivalent to drug tolerance and refers to subjects' reactions (positive or negative) to a drug reducing following its ...
IgE also plays a pivotal role in responses to allergens, such as anaphylactic reactions to drugs, bee stings, and antigen preparations used in desensitization immunotherapy. IgE is typically the least abundant isotype: blood serum IgE levels in a non- atopic individual are less than 0.0001% of the total Ig concentration, [ 10 ] compared to 75% ...
Anti-allergy immunotherapy. Allergen immunotherapy is useful for environmental allergies, allergies to insect bites, and asthma. [6] [131] Its benefit for food allergies is unclear and thus not recommended. [6] Immunotherapy involves exposing people to larger and larger amounts of allergen in an effort to change the immune system's response. [6]
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