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For some women, tamoxifen can cause a rapid increase in triglyceride concentration in the blood. In addition, there is an increased risk of thromboembolism especially during and immediately after major surgery or periods of immobility. [ 53 ]
Few tamoxifen users have had increased rates of uterine cancer, hot flushes, and thromboembolisms. The drug can also cause hepatocarcinomas in rats. This is likely due to the ethyl group of the tamoxifen stilbene core that is subject to allylic oxidative activation causing DNA alkylation and strand scission.
These fluctuations cause many of the physical changes during perimenopause as well as menopause, especially during the last 1–2 years of perimenopause (before menopause). [ 71 ] [ 75 ] Some of these changes are hot flashes , night sweats , difficulty sleeping, mood swings, vaginal dryness or atrophy , incontinence , osteoporosis , and heart ...
Menopause and sex lives at the intersection of women’s pain, pleasure, and aging, all topics that somehow still—in 2023—make doctors (and society at large) glitch, leaving women to suffer in ...
The Women's Health Initiative (WHI) is an ongoing study of over 27,000 women that began in 1991, with the most recent analyses suggesting that, when initiated within 10 years of menopause, HRT reduces all-cause mortality and risks of coronary disease, osteoporosis, and dementia; after 10 years the beneficial effects on mortality and coronary ...
Menopause is associated with a rapid decline of estrogen, as well as a steady rate of decline of androgens. [12] The decline of estrogen and androgen levels is believed to account for the lowered levels of sexual desire and motivation in postmenopausal women, although the direct relationship is not well understood.
Does Low Estrogen Cause Hair Loss? The short answer is yes, particularly during menopause. In fact, we can blame a lot on hormonal changes, from unexpected tears to hot flashes, drive fluctuations ...
In women, estrogens can additionally cause vaginal bleeding, vaginal discharge, and anovulation, whereas in men, estrogens can additionally cause gynecomastia (male breast development), feminization, demasculinization, sexual dysfunction (reduced libido and erectile dysfunction), hypogonadism, testicular atrophy, and infertility.